Improve the Cell Culture Process— Label-Free, Quantitative Results

Label-Free Cell Monitoring

With the CM20 monitoring system, there is no need to stain or detach the cultures to check their status. The system acquires data from label-free cells, reducing the chance of harm to your cultures.

Multipoint Cell Culture Monitoring

The head scans multiple points in your culture vessel to track the health and confluency of your cell cultures.

Consistent Results Throughout Your Lab

Constant Analysis Parameters

The CM20 system automatically measures cell conditions using constant analysis parameters, helping eliminate variability in analysis results introduced by different operators.

Reproducible Cell Observation Data

The monitor automatically records observation data that can be easily stored, reused, and transferred to help reduce training time or ensure that different labs are using the same analysis parameters.

Compare Data Across Samples

Using multiple heads helps you maintain a control sample while multiple test protocols run at the same time. Share your data with team members or compare it to past data.

Cost Effective

Accurately Time Cell Passage

You can set a notification in the system to alert you when cells are ready for passage.

Identify Abnormalities Early in the Process

By comparing current and past data, you can detect an abnormal cell culture earlier in the process, saving time and minimizing the use of expensive lab consumables on unusable cell cultures.

Reduce Your Sample Cost

Since the CM20 collects data on label-free cells, there is no need to grow the extra samples that are normally destroyed during the staining and peeling process.


Development Department
Mr. Yoshihito Tachi

I’m in charge of research and development of an autologous chondrocyte kit and conduct cell culture under various conditions when examining the culture protocol. I previously used a microscope to observe the conditions of cultured cells, but I can only make a qualitative evaluation with this method. Another challenge is that the analysis results vary depending on the experience and subjectivity of the worker. In contrast, the Olympus CM20 system can count cells and measure confluency with the same constant analysis parameters for highly reproducible and consistent analysis results. We can compare data between experiments when changing culture conditions, compare it with past data, and easily share it within the team, all of which can help us improve development efficiency. We’re also considering using it as an educational tool. By seeing the indicators, such as adhesion rate, uniformity, and proliferative ability, we can better evaluate the skills of workers.

Olympus RMS CORP. is a joint venture between the Olympus CORP. and SEWON CELLONTECH CORP. of South Korea.

Applied Technology

Supports Multi-Well Microplates (β ver.)

Expands compatibility with multi-well plates for up to 96 wells. Monitor and compare the culture status of multiple wells at the same time under different conditions. Supported multi-well plate formats include:

  • 24 well
  • 48 well
  • 96 well

Download β version software

Application Program Interface (API) to Freely Control the Acquisition Parameters
(β ver.)

Remote, independent control of the CM20 head to:

Set key parameters

  • Illumination
  • Stage (XY, Z)
  • Focus(autofocus/ manual focus)
  • Exposure and image capture

Acquire images and data

  • Static image capture
  • Live preview
  • Acquire and delete image data
  • Obtain the list of images

Download β version software

Customize the Settings to Meet Your Needs (β ver.)

Monitoring points

Set the monitoring points in the vessel and well plate anywhere you would like, as shown in the vessel on the right.

Focus position

Freely set the focus position for each monitoring point.

Monitoring time

Freely set the start time and interval time.

Download β version software

Flat Design Accommodates Various Vessels

Olympus’ epi-oblique optical system enables the CM20 incubation monitoring system to have a compact, flat design that accommodates most standard cell culture vessels. Simply place the culture vessel you normally use on CM20.

Learn more about epi-obique optical system